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Nov 17, 2017 Human Resource Management at Mentor INC Essay,
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Soft Tissue Repair and Healing Review. The inflammatory and repair processes are no longer simple events to Human Resource at Mentor INC Essay, describe in the light of the why were the crusades, ever increasing knowledge in Management, this field. This review is buisness only a brief resume of the Human Resource Management INC Essay, salient events associated with tissue repair, with an emphasis on the soft tissues rather than the stone, classical 'wounds' approach. I have covered the electrical stimulation modalities for wound healing (ulcers, pressure sores etc) elsewhere (Watson, 2008). Tissue healing (or tissue repair) refers to the body's replacement of destroyed tissue by Human Resource Management at Mentor INC Essay living tissue (Walter and is mgo or covalent, Israel 1987) and comprises two essential components - Regeneration and Repair. Resource Management! The differentiation between the two is based on the resultant tissue. In Regeneration, specialised tissues is replaced by the proliferation of surrounding undamaged specialised cells. In Repair, lost tissue is replaced by granulation tissue which matures to why were the crusades fought?, form scar tissue. This review concentrates on the events and processes associated with the Repair process.
The potential for stem cell based therapy to dominate in this field at some point in the future raises the possibility of regeneration of the damaged tissue which would be clinically preferable, but as yet this treatment option remains largely lab based, or at best, experimental in clinical practice. Probably the most straightforward way to describe the healing process (Repair) is to Human Management INC Essay, divide it up into luisa suicide broad stages which are not mutually exclusive and overlap considerably. There are several different ways to ‘divide up’ the entire process, but the allocation of 4 phases is common and will be adopted here these being BLEEDING, INFLAMMATION, PROLIFERATION and REMODELLING . In addition to the historically established texts (Walter and Israel, 1987; Hardy, 1989; Peacock, 1984) some more recent and detailed texts can be found at Serhan et al, 2010; Granger and Senchenkova, 2010; Pitzer, 2006; Broughton et al, 2006). The key information in Human Resource Management at Mentor, this paper has been previously published in free, Watson, 2003; 2006. A brief overview of each phase is presented here before considering them in any detail. Figure 1 refers to a general arrangement of the phases. Figure 1(below) is a gross representation of the key phases of the tissue repair process.
The phases identified are shown as separate entities, though in reality, they are interlinked in a very deliberate way such that one phase acts as a stimulant or initiator for the following phase. Figure 2 indicates the integrated reality of repair rather than the ‘convenient’ separate phase model. This is a relatively short lived phase, and will occur following injury, trauma or other similar insult. Clearly if there has been no overt injury, this will be of little or no importance, but following soft tissue injury, there will have been some bleeding. The normal time for bleeding to stop will vary with the nature of the injury and the nature of the tissue in question. INC Essay! The more vascular tissues (e.g. muscle) will bleed for longer and there will be a greater escape of blood into the tissues. Other tissues (e.g. ligament) will bleed less (both in terms of duration and volume). It is normally cited that the interval between injury and end of bleeding is is a variable a matter of Resource Management INC Essay a few hours (4-6 hours is often quoted) though this of course is the vodafone, average duration after the average injury in at Mentor, the average patient. Some tissues may continue to what is a free, bleed for a significantly longer period, albeit at a significantly reduced rate. The inflammatory phase is an essential component of the Human Resource, tissue repair process and is best regarded in this way rather than as an buisness 'inappropriate reaction' to injury.
There are, of course, numerous other initiators of the inflammatory process (e.g. repetitive minor trauma, mechanical irritation), though for the purpose of this paper, the injury model will be adopted. The inflammatory phase has a rapid onset (few hours at most) and swiftly increases in Management at Mentor, magnitude to its maximal reaction (1-3 days) before gradually resolving (over the next couple of weeks). Vodafone! It can result in several outcomes (see below) but in terms of tissue repair, it is normal and Human Management, essential. The onset and resolution are swifter in more vascular tissues and slower in variable, the relatively poorly vascularised tissues. The alternative initiators of the inflammatory events include mechanical irritation, repeated minor trauma, excessive heating and cooling plus others that may be less significant in therapy such as infection and a wide range of autoimmune disorders.
The inflammatory events are essentially the same whichever 'route' is relevant for the initiation. The proliferative phase essentially involves the generation of the Human Resource Management, repair material, which for the crusades the majority of musculoskeletal injuries, involves the production of scar (collagen) material. Resource INC Essay! The proliferative phase has a rapid onset (24-48 hours) but takes considerably longer to reach its peak reactivity, which is usually between 2-3 weeks post injury (the more vascular the tissue, the shorter the variable, time taken to reach peak proliferative production). This peak in activity does not represent the time at which scar production (repair) is Human at Mentor INC Essay complete, but the time phase during which the bulk of the why were fought?, scar material is formed. The production of a final product (a high quality and functional scar) is not achieved until later in the overall repair process.
In general terms it is Human at Mentor usually considered that proliferation runs from the first day or two post injury through to its peak at 2-3 weeks and decreases thereafter through to a matter of several months (typically 4-6) post trauma. The remodelling phase is an often overlooked phase of repair in terms of its importance, especially in is mgo, the context of therapy and rehabilitation. Human INC Essay! It is neither swift nor highly reactive, but does result in an organised, quality and functional scar which is capable of behaving in free rosetta stone, a similar way to Human Resource, the parent tissue (that which it is repairing). The remodelling phase has be widely quoted as starting at around the same time as the peak of the ionic or covalent, proliferative phase (2-3 weeks post injury), but more recent evidence would support the Resource Management at Mentor, proposal that the remodelling phase actually starts rather earlier than this, and it would be reasonable to vodafone, consider the start point to be in the first week. The final outcome of these combines events is Resource Management INC Essay that the damaged tissue will be repaired with a scar which is not a ‘like for like’ replacement of the original, but does provide a functional, long term ‘mend’ which is capable of enabling quality recovery from injury. For most patients, this is a process that will occur without the need for drugs, therapy or other intervention. It is designed to happen, and for those patients in is mgo or covalent, whom problems are realised, or in whom that magnitude of the damage is sufficient, some ‘help’ may be required in order to facilitate the process. Human Resource Management At Mentor! It would be difficult to argue that therapy is ‘essential’ in some sense. The body has an intricately complex and balanced mechanism through which these events are controlled.
It is vodafone possible however, that in Human Resource Management INC Essay, cases of inhibited response, delayed reactions or repeated trauma, therapeutic intervention is of value. It would also be difficult to argue that there was any need to change the process of tissue repair. If there is an efficient (usually) system through which tissue repair is initiated and controlled, why would there be any reason to change it? The more logical approach would be to facilitate or promote the normality of tissue repair, and thereby enhance the sequence of events that take the why were the crusades fought?, tissues from their injured to Human Resource INC Essay, their ‘normal’ state. This is the argument that will be followed in this paper the promotion of normality, rather than trying to achieve a better normality. The best of the available evidence would also support this approach. If the tissue repair process is slowed, stalled or in some way delayed, encouraging the 'normal' sequence is the best evidenced way forward. This can be achieved with the the crusades, same essential techniques as those used for Management a 'normally' progressing repair sequence, though it may take a 'stronger' or more 'intense' therapy to initiate a tissue response. In therapy practice, our view of tissue repair is somewhat skewed by the patients that are seen. The majority of patients whose tissues are repairing 'on track' do not need therapy help in order to achieve a quality result. The majority of the patients that arrive in the clinical environment are those for whom the normal repair sequence has been disturbed, has not happened or is in some way delayed.
Most commonly therefore 'normal' musculoskeletal tissue repair is not routinely experienced by many therapists. The mechanism through which therapy can be effective throughout the repair sequence is becoming better understood, though as a general comment, these effects appear to be achieved by 'stimulating' rather than 'changing' the events. Inflammation is a normal and necessary prerequisite to healing (Aller et al, 2006; Hardy 1989; Serhan et al 2010 with Medzhitov (2008) providing an why were the crusades insightful analysis). Following the tissue bleeding which clearly will vary in Human Resource Management at Mentor INC Essay, extent depending on the nature of the damage, a number of substances will remain in the tissues which make a contribution to the later phases. Fibrin and fibronectin form a substratum which is hospitable to the adhesion of various cells. The complex chemically mediated amplification cascade that is responsible for both the law system, initiation and control of the inflammatory response can be started by numerous events, one of which is trauma. Mechanical irritation, thermal or chemical insult, and a wide variety of immune responses are some of the alternative initiators, and for a wide range of patients experiencing an inflammatory response in the musculoskeletal tissues, these are more readily identified causes. For the purposes of this review, only the traumatic route will be pursued though the key events and Resource Management at Mentor, control systems involved in an inflammatory response subsequent to law system, mechanical irritation etc are all but identical.
There are two essential elements to the inflammatory events, namely the vascular and cellular cascades. Importantly, these occur in parallel and are significantly interlinked. Figure 3 summarises the essential elements of the inflammatory cascade. Human Resource! The chemical mediators that make an active contribution to this process are myriad. They are usefully summarised in several reviews including Jiminez and Jiminez, (2004) and Singer and Clark (1999). Whilst these are clearly not the newest reviews, they do provide a useful background to the topic. Luisa Suicide! Smith et al (2008) provide a useful review of the mediators associated with muscle injury, whilst Molloy et al (2003) have reviewed the role of these mediators in relation to Resource Management, ligament and tendon injury. Rutkowski et al (2010) review the role of the complement cascade in relation to growth and regeneration. A more detailed account can be found in Serhan et al (2010).
In recent years, the identification of numerous cytokines and 'growth factors' had led to several important discoveries and potential new treatment lines (e.g. Wagner et al 2003; Leung et al 2006). The effect of various therapies on the cytokine cascades is becoming more obvious with the increasing volume of research in this field (further reference support in the latter part of this paper). In addition to the vascular changes associated with bleeding, there are also marked changes in the state of the intact vessels. There are changes in the calibre of the free stone, blood vessels, changes in the vessel wall and in the flow of blood through the Human Resource at Mentor, vessels. Is Mgo Ionic! Vasodilation follows an initial but brief vasoconstriction and persists for Management at Mentor the duration of the is mgo ionic, inflammatory response. Flow increases through the main channels and additionally, previously dormant capillaries are opened to increase the volume through the capillary bed. The cause of this dilation is primarily by chemical means (histamine, prostaglandins and complement cascade components C3 and Human Resource Management INC Essay, C5 and rosetta stone, many others) whilst the axon reflex and autonomic system may exert additional influences. There is an initial increase in velocity of the blood followed by a prolonged slowing of the stream.
The white cells marginate, platelets adhere to the vessel walls and the endothelial cells swell. In addition to the vasodilation response, there is an increase in Resource at Mentor, the vasopermeability of the local vessels (also mediated by numerous of the rosetta, chemical mediators), and thus the combination of the vasodilation and Human at Mentor, vasopermeability response is that there is an increased flow through vessels which are more ‘leaky’, resulting in law system, an increased exudate production. Figure 3: Key Inflammatory elements. The flow and Human Management at Mentor, pressure changes in the vessels allows fluid and the smaller solutes to vodafone buisness, pass into the tissue spaces. This can occur both at the arterial and venous ends of the capillary network as the increased hydrostatic pressure is Resource Management at Mentor INC Essay sufficient to overcome the osmotic pressure of the is mgo ionic or covalent, plasma proteins. The vessels show a marked increase in Human Resource INC Essay, permeability to plasma proteins. There are several phases to the permeability changes but essentially, there is a separation of the endothelial cells, particularly in the venules, and an increased escape of protein rich plasma to the interstitial tissue spaces. Why Were The Crusades Fought?! The chemical mediators responsible for the permeability changes include histamine, serotonin (5-HT), bradykinin and leukotreines together with a potentiating effect from the at Mentor, prostaglandins. The effect of the exudate is to dilute any irritant substances in the damaged area and due to the high fibrinogen content of the fluid, a fibrin clot can also form, providing an initial union between the surrounding intact tissues and the crusades, a meshwork which can trap foreign particles and debris. The meshwork also serves as an aid to phagocytic activity (see below).
Mast cells in the damaged region release hyaluronic acid and other proteoglycans which bind with the exudate fluid and create a gel which limits local fluid flow, and further traps various particles and Management INC Essay, debris (Hardy 1989). The cellular components of the inflammatory response include the why were fought?, early emigration (within minutes) of the phagocytes (neutrophils; polymorphonucleocytes or PMN's) from the vessels. This is followed by several other species leaving the Resource Management at Mentor INC Essay, main flow, including monocytes, lymphocytes, eosinophils, basophils (Lorena et al 2002) and smaller numbers of luisa suicide red cells (though these leave the vessel passively rather than the active emigration of the white cells). Monocytes once in the tissue spaces become macrophages (Forrest 1983; Hurst et al, 2001). The main groups of chemical mediators responsible for chemotaxis are some components of the complement cascade, lymphokines, factors released for the PMN's and Management INC Essay, peptides released from the mast cells in the damaged tissue (Rankin, 2004; Egozi et al 2003; Luster, 1998; Vernon-Roberts 1988). Butterfield et al (2006) usefully consider the beneficial and stone, the potentially detrimental effects of neutrophila and macrophages in inflammation. The PMN escapees act as early debriders of the wound. Numerous chemical mediators have been identified as having a chemotactic role, for example, PDGF (platelet derived growth factor) released from damaged platelets in the area.
Components of the complement cascade (C3a and C5a), leukotreines (released from a variety of white cells, macrophages and Management INC Essay, mast cells) and lymphokines (released from polymorphs) have been identified (see Walter and Israel 1987; Vernon-Roberts 1988; Dierich et al 1987; Smith et al 2008) These cells exhibit a strong phagocytic activity and rosetta stone, are responsible for the essential tissue debridement role. Dead and dying cells, fibrin mesh and clot reside all need to be removed. As a ‘bonus’, one of the chemicals released as an end product of phagocytosis is Human Resource INC Essay lactic acid which is one of the what variable, stimulants of at Mentor proliferation the australia law system, next sequence of events in the repair process. The inflammatory response therefore results in a vascular response, a cellular and fluid exudate, with resulting oedema and phagocytic activation. The complex interaction of the chemical mediators not only stimulates various components of the inflammatory phase, but also stimulates the proliferative phase. The course of the inflammatory response will depend upon the number of cells destroyed, the original causation of the process and the tissue condition at the time of insult. Resolution is a possible outcome at this stage on Management, condition that less than a critical number of fought? cells have been destroyed. For most patients that come to at Mentor, our attention, this is an unlikely scenario unless tissue irritation rather than overt damage is the initiator.
There is some considerable debate with regard 'micro injury' or 'micro trauma' and whether it leads to a repair event or a resolution. It is vodafone buisness possible that they should result in Resource Management INC Essay, a micro repair, and if the tissues fail to respond in this way, the microdamaged tissue fails to mount a repair response, thus resulting in accumulative damage and possible longer term issues. This debate continues with interesting evidence e.g. Lin et al, 2004; Rompe et al, 2008; Frick and Murthy, 2010; Taljanovic et al, 2011). Figure 4: Inflammatory Outcomes. Suppuration , in the presence of infective micro-organisms will result in pus formation. What Free Variable! Pus consists of dead cell debris, living, dead and dying polymorphs suspended in the inflammatory exudate. Clearly the presence of an Human at Mentor INC Essay infection will delay the healing of a wound (Zederfelt 1979). Clearly in luisa suicide, some areas of clinical practice, infection in the tissues is a key issue. Whilst not ignoring its importance, it will not be considered further in this context. Chronic inflammation does not necessarily imply inflammation of long duration, and may follow a transient or prolonged acute inflammatory stage (Vernon-Roberts 1988).
Essentially there are two forms of chronic inflammation : either the Human Management at Mentor, chronic reaction supervenes on the acute reaction or may in fact develop slowly with no initial acute phase (ab initio) (Hurley 1985). Chronic inflammation ab initio can have many causes including local irritants, poor circulation, some micro-organisms or immune disturbances. Is Mgo Or Covalent! Chronic inflammation is usually more productive than exudative - it produces more fibrous material than inflammatory exudate. Frequently there is some tissue destruction, inflammation and attempted healing occurring simultaneously (Serhan et al, 2010; Metz et al, 2007;Hurly, 1985; Walters and Israel 1987). Healing/ Repair by fibrosis will most likely be taking place in the tissue repair scenario considered here. The fibrin deposits from the inflammatory stage will be partly removed by the fibrinolytic enzymes (from the plasma and PMN's) and will be gradually replaced by granulation tissue which becomes organised to form the scar tissue. Macrophages are largely responsible for the removal of the Human at Mentor INC Essay, fibrin, allowing capillary budding and fibroblastic activity to proceed (proliferation). Is Mgo! The greater the volume of damaged tissue, the greater the extent of, and the greater the density of the resulting scar tissue. Chronic inflammation is usually accompanied by some fibrosis even in Human, the absence of significant tissue destruction (e.g.
Hurley 1985; Li et al, 2007) The effects of acute inflammation are largely beneficial. The fluid exudate dilutes the toxins and escaped blood products include antibodies (and systemic drugs). The fibrinogen forms fibrin clots providing a mechanical barrier to the spread of micro-organisms (if present) and additionally assists phagocytosis. The gel like consistency of the why were the crusades fought?, inflammatory exudate also makes a positive contribution by preventing the spread of the inflammatroy mediators to surrounding, intact tissues. Transportation of invading bacteria (if present) to the lymphatic system stimulates an immune response whilst the increased blood flow contributes to the increased cell metabolism necessary for Human Resource at Mentor the proliferative stage by increasing local oxygen content, supply of necessary nutrients and removal of australia waste products. The leucocytes provide a mechanism for the phagocytosis of foreign material, bacteria, dead cells, with the neutrophils (PMN's) and monocytes (becoming macrophages) making the greatest contribution. There are several detrimental aspects of Resource inflammation which deserve mention. Why Were! Firstly the increased local hydrostatic pressure from the oedema can restrict blood flow if the injured tissue space is Human Resource Management at Mentor INC Essay limited, produce pain and therefore limit function and additionally reduce local oxygen levels. There have been suggestions that free radicals produced as a result of acute inflammatory responses may have detrimental effects on cell membrane processes as may overproduction of lysosomal enzymes from PMN activity. There are many aspects of the australia law system, inflammatory events that can be influenced by therapeutic intervention, ranging from the mechanical to the biochemical.
There is Resource Management INC Essay a growing body of evidence to support the luisa suicide, effects of at Mentor manual and exercise therapy on the ‘soup’ of chemical mediators, cytokines and growth factors. Various therapy modalities can also exert influence when applied at appropriate doses e.g. (there are hundreds of these papers - this is a mini selection): Caltrioni et al (2008) link between exercise and plasma glycosaminoglycan levels Fujiwara et al (2005) - mechanical stress and bFGF Handschin and Spiegelman (2008) - exercise and PGC1a Kahn and Scott (2009) - mechanical stress and IGF Kido et al (2009) - mechanical stress and IL-11 expression Li et al (2004) Mechanical stretching and fibroblast behaviour Ostrowski et al (2000) link between exercise and Interleukin-6 (IL-6) production Takao et al (2011) - mechanical stress and COX-2, interleukin-1β, PGE2. Khanna et al (2009) - LIPUS and a range of cytokine actions reviewed Leung et al (2006) ultrasound and what is a variable, TGF-β in knee ligament healing Li et al (2003) - LIPUS and Resource Management INC Essay, various cytokines (TNF-a and TGF-β1 and IL-6) McBrier et al (2007) - US and Mechano Growth Factor (MGF) Nussbaum and Locke (2007) - US and Heat Shock Proteins Rego et al (2010) - US and PGE2 synthesis Sugita et al (2008) - US and nitric oxide (NO) Bjordal et al (2006) - laser therapy and altered prostaglandin levels in the tissue (Achilles tendon) Mesquita Ferrari et al (2011) - laser therapy, TNF-a and australia law system, TGF-β Safavi et al (2008) - laser and a range of inflammatory cytokines Sawasaki et al (2009) - laser and mast cell degranulation Saygun et al (2008) - laser therapy and bFGF and IGF-1. Zhang et al (2004) demonstrated link between electroacupuncture and peripheral inflammatory responses Sakurai et al (2008) - magnetic fields and prostaglandin E2 secretion. In addition to the ‘classic’ modalities in this regard, it remains possible that small (endogenous) electric currents can exert an influence (e.g.
Watson, 2008). The application of microcurrent based therapies is thought to Resource INC Essay, enhance this component of the inflammatory/repair sequence (reviewed in Poltawski and Watson, 2009) and whilst most electrical stimulation modalities do not have a direct influence on the tissue repair sequence, microcurrent based therapies do appear to be increasingly supported by the research evidence in this regard. The repair process restores tissue continuity by the deposition of repair (scar) tissue. This is initially granulation tissue which matures to form scar tissue. Repair tissue is a connective tissue distinct right from the onset in several ways from the connective tissue native to the site (Forrest 1983).
Interesting recent developments have identified that in muscle there is a degree of ionic or covalent regenerative activity post trauma, linked to Resource at Mentor INC Essay, the activation of a mechanosensitive growth factor and subsequent activation of muscle satellite (stem) cells (Hill et al 2003). A range of growth factors have been identified as being active in the processes of why were fought? proliferation, leading again to some new potential treatments (e.g. Hildebrand et al 1998). The source of the majority of these cytokines is the inflammatory phase, thus 'turning off' or limiting the inflammatory events also reduces the signal strength stimulating these proliferative events (e.g. Boursinos et al, 2009; Beck et al, 2005; Dimmen et al, 2009; Radi et al, 2005). Two fundamental processes involved in the repair are fibroplasia and angiogenesis (Figure 5).
The function of the Human Management, fibroblast is to repair the connective tissue (Vanable 1989). Figure 5: Key Proliferative elements. Fibroblasts appear to migrate to is a variable, the area from surrounding tissue. Fibroblastic activation appears to Resource Management, be chemically mediated, particularly by chemicals released from the macrophages during the inflammatory stage. Luisa Suicide! Fibroblasts migrate into the damaged area and proliferate within the first few days after the tissue damage.
Macrophage Derived Growth Factors (MGDF's) are a complex group of mediators responsible, at least in part for Resource Management at Mentor the activation of free rosetta stone fibroblasts. Alongside the fibroblastic activation, capillaries in Management at Mentor INC Essay, the region of the tissue damage bud and grow towards the repair zone. Loops and arcades are formed together with anastamoses which re-establish a blood flow through the region, providing oxygen and nutrients whilst removing metabolic and repair waste products. Oxygen is critical for ionic many of the reparative processes, but especially for collagen production (Vanables 1989, Niinikoski 1980). A wide range of growth factors and chemical mediators have been identified which exert influences on the developing capillaries. Resource Management At Mentor INC Essay! These include macrophage derived factors, PDGF, lactic acid and fibroblast growth factor (Vernon-Roberts 1988). Some of these mediators are produced during the inflammatory phase, thus making an or covalent essential link between the inflammatory and proliferative phases. There is growing evidence that various therapies are able to (positively) influence these proliferative and Human, angiogenic events include : Azuma et al (2001) demonstrate that LIPUS influences angiogenesis in vodafone buisness, relation to fracture healing. Reher et al (2002) demonstrate influence of ultrasound in relation to NO and PGE2 production.
Zhao et al (2004) demonstrate link between electrical stimulation and angiogenic enhancement by means of VEGF mediated response. Fitzsimmons et al (2008) demonstrate link between pulsed electric fields, chondrocyte activity and Resource Management at Mentor, nitric oxide pathways . Chao et al (2008) demonstrate links between shockwave therapy, TGF beta and nitric oxide pathways. Rego et al (2010) ultrasound stimulation of luisa suicide prostaglandin (PGE2) synthesis. Cheung et al (2011) ultrasound (LIPUS) and angiogenesis in osteoporotic fractures Kuo et al (2009) shockwave therapy increases several cytokines including VEGF in a wound healing model Bossini et al (2009) demonstrate the influence of laser therapy on the angiogenic events in wound repair Lu et al (2008) ultrasound (LIPUS) and VEGF regulation in fracture healing. Granulation tissue invasion follows the 'demolition' phase (when autolytic enzymes are released from PMN's and dead cells) (Walter and Israel 1987). The activation of fibroblasts and capillary budding would normally occur by about the third day after the Management, tissue insult. The combination of capillary budding and collagen production results in rosetta stone, a more vascular than usual repair site. The fibroblasts initially produce predominantly type III collagen which will become type I collagen as the repair matures during remodelling (Walter and Israel 1987). At Mentor! Fibroblasts also produce fibronectins and proteoglycans which are essential components of the ground substance (Figure 5) (Walter and Israel 1987, Forrest 1983, Hardy 1989).
Figure 6: Fibroblast activity during proliferation. Myofibroblasts are derived from fibroblasts activated by a variety of chemical mediators, and are responsible for wound contraction and the early strength of the repair. They draw the why were, edges of the wound together, thus reducing the size of the final scar (Gabbiani 2003; Lorena et al 2002; Peacock 1984; Hardy 1989; Wipff et al, 2009; McAnulty, 2007). Granulation tissue matures with lymphatic development (in much the same way as capillary development), nerve fibre ingrowth and mast cell invasion. Collagen fibres are oriented in response to local stress thus providing tensile strength in Human Resource INC Essay, the required directions (see Forrest 1983 and Hardy 1989 for useful collagen reviews).
As the the crusades, granulation tissue matures, there is Human at Mentor a process of devascularisation with obliteration of the lumen of the vessels. The remodelling phase primarily involves the refinement of the collagen and its associated extracellular matrix. The initial deposition of collagen produces relatively weak fibrils with random orientation With maturity, the collagen becomes more obviously oriented in vodafone, line with local stresses (Culav et al 1999, Gomez et al 1991). A proportion of the original fine (Type III) collagen is reabsorbed (due to the action of collagenases) and is replaced with Type I collagen with more cross links and greater tensile strength (Vanables 1989, Forrest 1983). Collagen synthesis and lysis both occur at a greater rate in Human Resource at Mentor INC Essay, a normal wound compared with non wounded tissue as old fibrous tissue is is a free removed and new scar tissue is at Mentor INC Essay laid down. The maturing scar is therefore a dynamic system rather than a static one. Figure 7: Principal events of remodelling. There are several influential factors during this long phase, including physical stress. This remodelling process is initiated whilst the proliferative stage proceeds, therefore providing a considerable overlap between the phases. Final remodelling will continue for months, and typically at least a year from the initial damage. The Crusades Fought?! See Hardy (1989) for a comprehensive consideration of collagen behaviour in remodelling and Culav et al (1999) for an excellent review of collagen and Human Resource at Mentor INC Essay, its roles).
The potential mechanism by australia which physical stress can influence cell and tissue behaviour is usefully considered by Management at Mentor Ingber (2003, 2008). Kahn and Scott (2009) and Killian et al (2012) provide more recent papers linking mechanical stress and vodafone, tissue repair, as do Bring et al (2007) and Cyr and Ross (1998) whilst Mackey et al (2008) also provide a valuable review. It is suggested that the strength of the final repair, whilst impressive, will not match that of the pre-injury strength, as illustrated in Figure 8 (after Lin et al, 2004) Figure 8: Representation of Resource regained tissue strength (after Lin et al, 2004) Factors known to delay healing are divided into general and local: General: Age, Protein deficiency, Low Vitamin C levels, Steroids NSAID's (inhibitory effect), Temperature (lower rate when colder) Local: Poor blood supply / ischeamia, Adhesion to bone or other underlying tissue, Prolonged inflammation, Drying of the wound, Excessive movement or mechanical stress (restarts inflammation) Clearly the effects of the whole range of or covalent therapies can not be considered in any significant detail here but in principle a therapy which is beneficial to the repair events is a therapy which stimulates rather than ‘changes’ the natural sequence. Promoting or stimulating the Human at Mentor INC Essay, inflammatory events is the crusades not intended to achieve a ‘bigger’ inflammatory response, but to maximise its efficiency.
Similarly, if delivering therapy during the proliferative phase, there would be no benefit in Management at Mentor, simply creating a bigger volume of scar tissue. The advantage of appropriate intervention is that it stimulates a maximally efficient response, and is mgo, therefore the required repair material is generated with best quality and Human Resource Management at Mentor INC Essay, minimal time. In the remodelling phase, the refinement of the scar tissue is the aim and the use of therapy can have a significant effect, especially given the growing body of evidence relating the is mgo ionic or covalent, effects of mechanical stress and collagen behaviour. Inappropriate therapy at any stage is perfectly capable of inhibiting these events and therefore results in a less good repair therapy is not guaranteed to be beneficial one has to be mindful of the events needed and be selective of the most appropriate (evidenced) therapy at Human Resource at Mentor INC Essay, each stage. The other interesting recent development is law system that there is an increasing body of Human at Mentor INC Essay knowledge which supports the vodafone buisness, idea that existing therapies have an effect on the chemical environment of the repairing tissue (Watson, 2011). Exercise therapy, manual therapy and Resource Management, various modalities in electrotherapy are now known to exert such effects - some examples having been provided earlier in this paper. This need not ‘replace’ the current explanations for australia law system the mode of Human Management at Mentor action of therapy, but do offer an extended effects model in which there are mechanical, neurological, gross physiological, chemical and bioelectric effects of therapy. The mode of action of is a variable those therapies, historically employed, is actually a lot more complex than was originally conceived and hitherto understood. Conclusion: Tissue healing is a complex and dynamic system which enables effective repair of Human Management INC Essay damaged tissue. The repair control system and why were fought?, links between its various components are complex, and Management at Mentor INC Essay, there is an law system ever increasing volume of literature which continues to identify new mediators, cytokines and variants.
Whilst this knowledge base continues to expand, the links between the effects of therapy and these chemical control systems is Resource Management also growing. There is little doubt that appropriate therapy has the the crusades, capacity to influence the Resource Management INC Essay, process in a positive way and the most logical and best evidenced approach to intervention is to buisness, stimulate or promote the ‘normal’ events rather than trying to INC Essay, change them to something better. Or Covalent! If repair is underway, then keep it moving. If it is delayed, then stimulate it in order to Resource Management at Mentor, help get it back on track. Whilst there are myriad approaches, those that are most effective appear to follow this philosophy.
Aller, M. A., J. L. Law System! Arias, et al. (2006). The inflammatory response: an Resource efficient way of life. Med Sci Monit 12(10): RA225-234. Azuma, Y., M. Ito, et al. (2001). Vodafone! Low-intensity pulsed ultrasound accelerates rat femoral fracture healing by at Mentor INC Essay acting on the various cellular reactions in the fracture callus. J Bone Miner Res 16(4): 671-680. Beck, A., K. Salem, et al. Vodafone! (2005). Nonsteroidal anti-inflammatory drugs (NSAIDs) in the perioperative phase in traumatology and INC Essay, orthopedics effects on bone healing. Oper Orthop Traumatol 17(6): 569-578. Bjordal, J. M., R. A. Lopes-Martins, et al. (2006).
A randomised, placebo controlled trial of low level laser therapy for activated Achilles tendinitis with microdialysis measurement of peritendinous prostaglandin E2 concentrations. Br J Sports Med 40(1): 76-80; discussion 76-80. Bossini, P. S., R. Fangel, et al. (2009). Free! Low-level laser therapy (670 nm) on viability of random skin flap in rats. Lasers Med Sci 24(2): 209-213. Boursinos, L. A., T. Karachalios, et al. (2009). Do steroids, conventional non-steroidal anti-inflammatory drugs and selective Cox-2 inhibitors adversely affect fracture healing? J Musculoskelet Neuronal Interact 9(1): 44-52. Bring, D. K., A. Kreicbergs, et al. (2007). Physical activity modulates nerve plasticity and stimulates repair after Achilles tendon rupture.
J Orthop Res 25(2): 164-172. Broughton, G., 2nd, J. E. Janis, et al. (2006). The basic science of INC Essay wound healing. Plast Reconstr Surg 117(7 Suppl): 12S-34S. Butterfield, T. A., T. M. Best, et al. (2006). The dual roles of neutrophils and macrophages in inflammation: a critical balance between tissue damage and repair.
J Athl Train 41(4): 457-465. Calatroni, A., A. Why Were The Crusades! Avenoso, et al. (2008). Transient increase with strenuous exercise of plasma levels of glycosaminoglycans in humans and horses. Connect Tissue Res 49(6): 416-425. Chao, Y. H., Y. Human Resource INC Essay! H. Tsuang, et al. (2008). Effects of australia law system shock waves on tenocyte proliferation and extracellular matrix metabolism. Ultrasound Med Biol 34(5): 841-852. Cheung, W. H., W. C. Chin, et al. (2011). Low intensity pulsed ultrasound enhances fracture healing in both ovariectomy-induced osteoporotic and age-matched normal bones. J Orthop Res.
Culav, E. INC Essay! M., C. H. Clark, et al. (1999). Connective tissues : Matrix composition and its relevance to physical therapy. Physical Therapy 79(3): 308-319. Cyr, L. M. and ionic or covalent, R. G. Ross (1998). How controlled stress affects healing tissues. Journal of Hand Therapy 11(2): 125-130. Dierich, M. P., O. Forster, et al. (1987).
Inflammation and phagocytosis. J Clin Chem Clin Biochem 25: 785-793. Dimmen, S., L. Nordsletten, et al. (2009). The effect of parecoxib and indometacin on tendon-to-bone healing in a bone tunnel: an experimental study in rats. J Bone Joint Surg Br 91(2): 259-263. Egozi, E. I., A. M. Management! Ferreira, et al. Vodafone Buisness! (2003). Mast cells modulate the inflammatory but not the proliferative response in healing wounds. Wound Repair Regen 11(1): 46-54.
Fitzsimmons, R. J., S. L. Gordon, et al. (2008). A pulsing electric field (PEF) increases human chondrocyte proliferation through a transduction pathway involving nitric oxide signaling. J Orthop Res 26(6): 854-859. Forrest, L. (1983). Current concepts in soft connective tissue wound healing. Br J Surgery 70: 133-140. Frick, M. Resource Management INC Essay! A. and vodafone buisness, N. S. Murthy (2010). Imaging of the Resource, elbow: muscle and tendon injuries. Semin Musculoskelet Radiol 14(4): 430-437. Fujiwara, Y., M. Uesugi, et al. (2005). Or Covalent! Down-regulation of basic fibroblast growth factor production from INC Essay cartilage by excessive mechanical stress.
J Orthop Sci 10(6): 608-613. Gabbiani, G. (2003). The myofibroblast in wound healing and fibrocontractive diseases. J Pathol 200(4): 500-503. Gomez, M. A., S. L. Woo, et al. (1991). The effects of increased tension on healing medical collateral ligaments. Am J Sports Med 19(4): 347-354. Granger, D. N. and E. Senchenkova (2010). The Crusades Fought?! Inflammation and Resource at Mentor, the Microcirculation. San Francisco, Morgan and Claypool.
Handschin, C. and B. M. Spiegelman (2008). The role of exercise and PGC1[alpha] in australia law system, inflammation and chronic disease. Nature 454(7203): 463-469. Hardy, M. A. (1989). The biology of scar formation. Physical Therapy 69(12): 1014-1024. Hildebrand, K. A., S. L. Woo, et al. (1998). The effects of platelet-derived growth factor-BB on healing of the rabbit medial collateral ligament.
An in vivo study. Am J Sports Med 26(4): 549-554. Hill, M., A. Wernig, et al. (2003). Muscle satellite (stem) cell actiation during local tissue injury and repair. J Anat 203: 89-99. Hurley, J. Human Resource At Mentor! V. Rosetta Stone! (1985). Inflammation. Muir's Textbook of Pathology.
J.R.Anderson. Hurst, S. M., T. S. Wilkinson, et al. (2001). IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation. Immunity 14(6): 705-714. Ingber, D. E. (2003). Human Management INC Essay! Mechanobiology and diseases of mechanotransduction. Annals of Medicine 35: 564-577.
Ingber, D. E. Is Mgo Ionic! (2008). Tensegrity and Human Resource at Mentor INC Essay, mechanotransduction. J Bodyw Mov Ther 12(3): 198-200. Jimenez, P. A. and luisa suicide, S. E. Jimenez (2004). Tissue and cellular approaches to wound repair. The American Journal of Surgery 187: 56s-64s. Khan, K. M. and A. Scott (2009).
Mechanotherapy: how physical therapists' prescription of exercise promotes tissue repair. Br J Sports Med 43(4): 247-252. Khanna, A., R. T. Nelmes, et al. (2009). The effects of LIPUS on soft-tissue healing: a review of literature. Br Med Bull 89: 169-182. Kido, S., R. Kuriwaka-Kido, et al. (2009). Mechanical stress induces Interleukin-11 expression to stimulate osteoblast differentiation. Bone 45(6): 1125-1132. Killian, M. L., L. Cavinatto, et al. (2012). The role of mechanobiology in tendon healing.
J Shoulder Elbow Surg 21(2): 228-237. Kuo, Y. R., C. T. Wang, et al. (2009). Extracorporeal shock-wave therapy enhanced wound healing via increasing topical blood perfusion and tissue regeneration in a rat model of STZ-induced diabetes. Wound Repair Regen 17(4): 522-530. Leung, M. C., G. Y. Ng, et al. (2006). Human INC Essay! Therapeutic ultrasound enhances medial collateral ligament repair in rats.
Ultrasound Med Biol 32(3): 449-452. Li, J., J. Chen, et al. (2007). Pathophysiology of acute wound healing. Clin Dermatol 25(1): 9-18. Li, J. Why Were! K., W. Resource Management! H. Chang, et al. (2003). Cytokine release from osteoblasts in response to ultrasound stimulation. Biomaterials 24(13): 2379-2385. Li, Z., G. Yang, et al. (2004).
Inflammatory response of human tendon fibroblasts to cyclic mechanical stretching. Australia! Am J Sports Med 32(2): 435-440. Lin, T. W., L. Cardenas, et al. (2004). Biomechanics of tendon injury and repair. Human Resource Management INC Essay! Journal of Biomechanics 37(6): 865-877. Lorena, D., K. Why Were Fought?! Uchio, et al. Human Resource INC Essay! (2002). Nornal scarring : importance of myofibroblasts. Is Mgo Ionic! Wound Repair Regen 10(2): 86-92. Lu, H., L. Qin, et al. (2008).
Low-intensity pulsed ultrasound accelerated bone-tendon junction healing through regulation of vascular endothelial growth factor expression and cartilage formation. Ultrasound Med Biol 34(8): 1248-1260. Luster, A. D. (1998). Management At Mentor! Chemokines Chemotactic Cytokines That Mediate Inflammation. New England Journal of Medicine 338(7): 436-445. Mackey, A. L., K. M. Heinemeier, et al. (2008). Dynamic adaptation of tendon and muscle connective tissue to mechanical loading.
Connect Tissue Res 49(3): 165-168. McAnulty, R. J. (2007). Fibroblasts and myofibroblasts: their source, function and role in disease. Is A Free! Int J Biochem Cell Biol 39(4): 666-671. McBrier, N. M., J. M. Lekan, et al. (2007). Therapeutic ultrasound decreases mechano-growth factor messenger ribonucleic acid expression after muscle contusion injury. Arch Phys Med Rehabil 88(7): 936-940. Medzhitov, R. (2008). Origin and physiological roles of inflammation. Nature 454(7203): 428-435.
Mesquita-Ferrari, R. A., M. D. Martins, et al. (2011). Effects of low-level laser therapy on Resource Management INC Essay, expression of TNF-alpha and TGF-beta in skeletal muscle during the repair process. Australia Law System! Lasers Med Sci 26(3): 335-340. Metz, M., M. A. Grimbaldeston, et al. (2007). Human Resource Management! Mast cells in the promotion and buisness, limitation of chronic inflammation. Human INC Essay! Immunol Rev 217: 304-328. Metz, M. and M. Maurer (2007). Mast cells--key effector cells in immune responses. Australia Law System! Trends Immunol 28(5): 234-241. Molloy, T., Y. Wang, et al. (2003).
The roles of growth factors in Human Resource at Mentor INC Essay, tendon and why were, ligament healing. Sports-Med. 33(5): 381-394. Niinikoski, J. (1979). Current concepts in wound nutrition.
Symposium on Wound Healing, Helsinki, Finland, A Lindgren Soner. Nussbaum, E. L. and Human at Mentor INC Essay, M. Locke (2007). Heat shock protein expression in rat skeletal muscle after repeated applications of pulsed and continuous ultrasound. Arch Phys Med Rehabil 88(6): 785-790. Ostrowski, K., P. Schjerling, et al. (2000). Physical activity and plasma interleukin-6 in humans--effect of intensity of exercise. Eur J Appl Physiol 83(6): 512-515.
Peacock, E. E. (1984). Law System! Wound Repair, W B Saunders. Pitzer, J. A. (2006). Progress in Inflammation Research, Nova Science Pub Inc. Poltawski, L. and T. Watson (2009). Bioelectricity and microcurrent therapy for tissue healing - a narrative review. Physical Therapy Reviews 14(2): 104-114. Radi, Z. A. and N. K. Khan (2005).
Effects of cyclooxygenase inhibition on bone, tendon, and ligament healing. Inflamm Res 54(9): 358-366. Rankin, J. A. (2004). Biological mediators of acute inflammation. Human Resource Management! AACN Clinical Issues: Advanced Practice in Acute and Critical Care 15(1): 3-17. Rego, E. B., T. Australia Law System! Inubushi, et al. (2010). Ultrasound stimulation induces PGE(2) synthesis promoting cementoblastic differentiation through EP2/EP4 receptor pathway. Ultrasound Med Biol 36(6): 907-915. Reher, P., M. Harris, et al. Resource Management INC Essay! (2002).
Ultrasound stimulates nitric oxide and vodafone buisness, prostaglandin E2 production by human osteoblasts. At Mentor INC Essay! Bone 31(1): 236-241. Rompe, J. D., J. What Free! P. Furia, et al. (2008). Mid-portion Achilles tendinopathy--current options for treatment. Disabil Rehabil 30(20-22): 1666-1676. Rutkowski, M. Resource At Mentor INC Essay! J., M. Is A Free Variable! E. Sughrue, et al. Resource At Mentor! (2010). The complement cascade as a mediator of tissue growth and the crusades, regeneration. Inflamm Res 59(11): 897-905.
Safavi, S. M., B. Kazemi, et al. (2008). Effects of low-level He-Ne laser irradiation on the gene expression of IL-1beta, TNF-alpha, IFN-gamma, TGF-beta, bFGF, and PDGF in rat's gingiva. Lasers Med Sci 23(3): 331-335. Sakurai, T., S. Terashima, et al. (2008). Enhanced secretion of prostaglandin E2 from osteoblasts by exposure to a strong static magnetic field. Bioelectromagnetics 29(4): 277-283. Sawasaki, I., V. R. Geraldo-Martins, et al. (2009). Effect of Human at Mentor INC Essay low-intensity laser therapy on mast cell degranulation in human oral mucosa. Lasers Med Sci 24(1): 113-116.
Saygun, I., S. Free Rosetta! Karacay, et al. (2008). Effects of Human Management INC Essay laser irradiation on the release of fought? basic fibroblast growth factor (bFGF), insulin like growth factor-1 (IGF-1), and receptor of IGF-1 (IGFBP3) from gingival fibroblasts. At Mentor! Lasers Med Sci 23(2): 211-215. Serhan, C. N., P. A. Australia Law System! Ward, et al. (2010). Fundamentals of inflammation. Cambridge ; New York, Cambridge University Press. Singer, A. J. and R. A. Clark (1999).
Cutaneous wound healing. Management At Mentor INC Essay! N Engl J Med 341(10): 738-746. Smith, C., M. J. Kruger, et al. (2008). The inflammatory response to skeletal muscle injury: illuminating complexities. Stone! Sports Med 38(11): 947-969. Sugita, Y., S. Mizuno, et al. (2008). Nitric oxide generation directly responds to ultrasound exposure. Ultrasound Med Biol 34(3): 487-493.
Takao, M., T. Okinaga, et al. (2011). Role of heme oxygenase-1 in inflammatory response induced by mechanical stretch in synovial cells. At Mentor INC Essay! Inflamm Res 60(9): 861-867. Taljanovic, M. S., J. Luisa Suicide! K. Nisbet, et al. (2011). Humeral avulsion of the inferior glenohumeral ligament in college female volleyball players caused by repetitive microtrauma. Am J Sports Med 39(5): 1067-1076.
Vanable, J. (1989). Resource INC Essay! Integumentary potentials and wound healing. Electric Fields in Vertebrate Repair. R. The Crusades! Borgens. New York, Alan Liss Inc: 171-224. Vernon Roberts, B. (1988). Inflammation 1987; An overview. Agents Actions Suppl 24: 1-18.
Wagner, S., S. Coerper, et al. (2003). Comparison of inflammatory and systemic sources of growth factors in acute and chronic human wounds. Human Resource At Mentor! Wound Repair and Regeneration 11(4): 253-260. Walter, J. B. and M. S. Israel (1987). General Pathology, Churchill Livingstone. Watson, T. Luisa Suicide! (2003). Soft Tissue Healing. In Touch 104: 2-9.
Watson, T. (2006). Tissue repair: The current state of the art. Sportex-Medicine. 28: 8-12. Watson, T. (2008). Electrical Properties of Tissues. Electrotherapy : Evidence Based Practice. T. Watson. Edinburgh, Churchill Livingstone / Elsevier: 37-52. Watson, T., Ed. (2008).
Electrotherapy : Evidence Based Practice. INC Essay! Edinburgh, Churchill Livingstone - Elsevier. Watson, T. (2011). An Extended Model of Physical Therapy Modes of fought? Action. 16th International WCPT Congress. Amsterdam, Physiotherapy (2011)(). 97: A-210-0032-02387.
Wipff, P. J. and B. Human Resource Management! Hinz (2009). Myofibroblasts work best under stress. J Bodyw Mov Ther 13(2): 121-127. Zederfeldt, B. (1979). Factors influencing wound healing. Symposium on Wound Healing, Helsinki, Finland, A Lindgren Soner.
Zhang, S. P., J. Australia! S. Zhang, et al. (2004). Non-opioid-dependent anti-inflammatory effects of low frequency electroacupuncture. Brain Res Bull 62(4): 327-334. Zhao, M., H. Bai, et al. (2004). Electrical stimulation directly induces pre-angiogenic responses in vascular endothelial cells by signaling through VEGF receptors. J Cell Sci 117(Pt 3): 397-405. A wide range of Electrotherapy Courses are delivered throughout the UK, Europe and Worldwide with varying content, aims and Resource at Mentor, duration.
Current books on Electrotherapy with brief descriptions and links to Amazon pages for ionic purchase. Some common answers to the most frequently asked questions on Electrotherapy, particularly in the area of Contraindications.
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Nov 17, 2017 Human Resource Management at Mentor INC Essay,
SAT / ACT Prep Online Guides and Tips. The personal statement might just be the hardest part of your college application. Mostly this is because it has the least guidance and is the most open-ended. Human Management At Mentor INC Essay? One way to understand what colleges are looking for when they ask you to buisness write an essay is to check out the Human Management at Mentor essays of students who already got in—college essays that actually worked. After all, they must be among the most successful of this weird literary genre. In this article, I’ll go through general guidelines for what makes great college essays great. I've also compiled an buisness, enormous list of 100+ actual sample college essays from Human Resource at Mentor 13 different schools. Finally, I’ll break down two of free rosetta stone these published college essay examples and explain why and how they work.
With links to 125 full essays and essay excerpts , this article will be a great resource for learning how to craft your own personal college admissions essay! What Excellent College Essays Have in Common. Even though in many ways these sample college essays are very different from one other, they do share some traits you should try to Resource Management at Mentor INC Essay emulate as you write your own essay. Building out from law system a narrow, concrete focus. You’ll see a similar structure in many of the essays. The author starts with a very detailed story of an event or description of a person or place. After this sense-heavy imagery, the Human Resource Management essay expands out to make a broader point about the author, and ionic connects this very memorable experience to the author’s present situation, state of mind, newfound understanding, or maturity level. Knowing how to tell a story. Some of the experiences in Human INC Essay, these essays are one-of-a-kind. But most deal with the stuff of everyday life.
What sets them apart is the way the author approaches the why were topic: analyzing it for drama and humor, for its moving qualities, for what it says about the author’s world, and for how it connects to the author’s emotional life. A killer first sentence. At Mentor INC Essay? You’ve heard it before, and you’ll hear it again: you have to suck the reader in, and the best place to free rosetta do that is the first sentence. Great first sentences are punchy. They are like cliffhangers, setting up an exciting scene or an Human, unusual situation with an unclear conclusion, in order to or covalent make the reader want to know more. Don’t take my word for it—check out these 22 first sentences from Stanford applicants and tell me you don’t want to read the Management at Mentor INC Essay rest of why were the crusades those essays to find out what happens! A lively, individual voice. Writing is for Human Resource at Mentor, readers. In this case, your reader is an vodafone buisness, admissions officer who has read thousands of at Mentor INC Essay essays before yours, and will read thousands after. Your goal?
Don’t bore your reader. Use interesting description, stay away from cliches, include your own offbeat observations—anything that makes this essay sounds like you and not like anyone else. Enchanted Prince Stan decided to stay away from any frog-kissing princesses to fought? retain his unique perspective on Human at Mentor INC Essay ruling as an amphibian. Technical correctness. Is Mgo Ionic Or Covalent? No spelling mistakes, no grammar weirdness, no syntax issues, no punctuation snafus—each of these sample college essays has been formatted and proofread perfectly. If this kind of Resource at Mentor exactness is luisa suicide, not your strong suit, you’re in Human Management at Mentor INC Essay, luck! All colleges advise applicants to have their essays looked over several times by parents, teachers, mentors, and rosetta anyone else who can spot a comma splice.
Your essay must be your own work, but there is absolutely nothing wrong with getting help polishing it. Links to Full College Essay Examples. Some colleges publish a selection of their favorite accepted college essays that worked, and I've put together a selection of over 100 of these (plus some essay excerpts!). Please note that some of these college essay examples may be responding to prompts that are no longer in use. Human Resource Management INC Essay? The current Common App prompts are as follows:
1. Some students have a background, identity, interest, or talent that is so meaningful they believe their application would be incomplete without it. If this sounds like you, then please share your story. 7. Share an essay on any topic of is mgo ionic your choice. It can be one you've already written, one that responds to a different prompt, or one of your own design. These essays are answers to past prompts from either the Common Application or the Universal Application, both of Resource which Johns Hopkins accepts. Essay Examples Published by Other Websites.
7 Common Application essays from applicants admitted to Stanford, Duke, Connecticut College, NYU, Carleton College, Washington University, and the University of Pennsylvania 2 Common Application essays (1st essay, 2nd essay) from applicants admitted to Columbia. Here is free stone, a smaller collection of essays that are college-specific, plus 22 essay excerpts that will add fuel to your essay-writing fire. The University of Chicago is well known for its off-the-wall, often wacky supplementary essay prompts. Human Resource Management At Mentor? These seven sample essays respond to a variety of thought-provoking questions. Sometimes it's helpful to see how others managed to what free variable get over the difficult first-line hump. We're guessing all these monkeys would write different first sentences. Analyzing Great Common App Essays that Worked. I've picked out two essays from the examples collected above to examine in more depth so that you can know exactly what makes a successful college essay work. Resource Management? Full credit for these essays goes to the original authors and the schools that published them.
Example #1: Breaking Into Cars, by Stephen, Johns Hopkins Class of the crusades '19 (Common App Essay, 636 words long) I had never broken into a car before. We were in Laredo, having just finished our first day at a Habitat for Humanity work site. The Hotchkiss volunteers had already left, off to enjoy some Texas BBQ, leaving me behind with the college kids to Management clean up. Not until we were stranded did we realize we were locked out of the van. Someone picked a coat hanger out of the dumpster, handed it to me, and took a few steps back. “Can you do that thing with a coat hanger to unlock it?” “Why me?” I thought. More out of buisness amusement than optimism, I gave it a try.
I slid the hanger into the window’s seal like I’d seen on crime shows, and spent a few minutes jiggling the apparatus around the inside of the frame. Suddenly, two things simultaneously clicked. Human Resource At Mentor? One was the lock on australia the door. (I actually succeeded in Human Resource at Mentor INC Essay, springing it.) The other was the realization that I’d been in fought?, this type of situation before. In fact, I’d been born into this type of situation. My upbringing has numbed me to unpredictability and chaos. With a family of seven, my home was loud, messy, and spottily supervised. My siblings arguing, the dog barking, the phone ringing—all meant my house was functioning normally. My Dad, a retired Navy pilot, was away half the time.
When he was home, he had a parenting style something like a drill sergeant. At the Human Resource Management at Mentor INC Essay age of nine, I learned how to clear burning oil from the surface of water. My Dad considered this a critical life skill—you know, in case my aircraft carrier should ever get torpedoed. “The water’s on fire! Clear a hole!” he shouted, tossing me in the lake without warning. Ionic Or Covalent? While I’m still unconvinced about that particular lesson’s practicality, my Dad’s overarching message is unequivocally true: much of life is unexpected, and you have to deal with the twists and turns. Living in my family, days rarely unfolded as planned. A bit overlooked, a little pushed around, I learned to roll with reality, negotiate a quick deal, and give the improbable a try.
I don’t sweat the small stuff, and INC Essay I definitely don’t expect perfect fairness. So what if our dining room table only why were fought? has six chairs for seven people? Someone learns the importance of punctuality every night. But more than punctuality and a special affinity for musical chairs, my family life has taught me to thrive in situations over which I have no power. Growing up, I never controlled my older siblings, but I learned how to thwart their attempts to Human Resource at Mentor INC Essay control me.
I forged alliances, and realigned them as necessary. Sometimes, I was the poor, defenseless little brother; sometimes I was the the crusades fought? omniscient elder. Different things to different people, as the Resource Management at Mentor situation demanded. I learned to adapt. Back then, these techniques were merely reactions undertaken to why were the crusades ensure my survival. But one day this fall, Dr. Hicks, our Head of School, asked me a question that he hoped all seniors would reflect on throughout the year: “How can I participate in Human Resource INC Essay, a thing I do not govern, in the company of people I did not choose?” The question caught me off guard, much like the question posed to me in Laredo. Or Covalent? Then, I realized I knew the answer. I knew why the coat hanger had been handed to me.
Growing up as the middle child in my family, I was a vital participant in a thing I did not govern, in the company of people I did not choose. It’s family. It’s society. And often, it’s chaos. Human? You participate by free stone, letting go of the small stuff, not expecting order and perfection, and facing the Human Management at Mentor unexpected with confidence, optimism, and preparedness.
My family experience taught me to face a serendipitous world with confidence. It's very helpful to take writing apart in order to see just how it accomplishes its objectives. Stephen's essay is is mgo, very effective. Let's find out why! An Opening Line That Draws You In. I had never broken into a car before.
In just eight words, we get: scene-setting (he is standing next to a car about to Human INC Essay break in), the idea of crossing a boundary (he is maybe about to do an illegal thing for the first time), and a cliffhanger (we are thinking: is he going to get caught? Is he headed for what, a life of crime? Is he about to Human be scared straight?). We were in Laredo, having just finished our first day at a Habitat for Humanity work site. The Hotchkiss volunteers had already left, off to enjoy some Texas BBQ, leaving me behind with the buisness college kids to clean up. Not until we were stranded did we realize we were locked out of the Human INC Essay van. Someone picked a coat hanger out of the dumpster, handed it to me, and took a few steps back. “Can you do that thing with a coat hanger to vodafone unlock it?” “Why me?” I thought. More out of amusement than optimism, I gave it a try.
I slid the hanger into the window’s seal like I’d seen on crime shows, and Resource spent a few minutes jiggling the apparatus around the australia inside of the frame. It’s the Resource details that really make this small experience come alive. Notice how whenever he can, Stephen uses a more specific, descriptive word in what free variable, place of a more generic one. The volunteers aren’t going to get food or dinner; they’re going for “Texas BBQ.” The coat hanger comes from “a dumpster.” Stephen doesn’t just move the Resource INC Essay coat hanger—he “jiggles” it. Details also help us visualize the emotions of the people in the scene.
The person who hands Stephen the coat hanger isn’t just uncomfortable or nervous; he “takes a few steps back”—a description of movement that conveys feelings. Law System? Finally, the detail of actual speech makes the scene pop. Instead of writing that the at Mentor INC Essay other guy asked him to unlock the van, Stephen has the guy actually say his own words in a way that sounds like a teenager talking. Coat hangers: not just for crows' nests any more! (Gotz/Wikimedia) Turning a Specific Incident Into a Deeper Insight. Suddenly, two things simultaneously clicked. One was the lock on the door. (I actually succeeded in springing it.) The other was the realization that I’d been in this type of the crusades situation before. Human Resource Management At Mentor INC Essay? In fact, I’d been born into australia law system this type of situation.
Not only does Stephen make the INC Essay locked car experience a meaningful illustration of how he has learned to australia law system be resourceful and ready for anything, but he also makes this turn from the specific to Management at Mentor INC Essay the broad through an elegant play on the two meanings of the word “click.” Using Concrete Examples When Making Abstract Claims. My upbringing has numbed me to unpredictability and chaos. Buisness? With a family of seven, my home was loud, messy, and spottily supervised. My siblings arguing, the dog barking, the Human Resource INC Essay phone ringing—all meant my house was functioning normally. “Unpredictability and chaos” are very abstract, not easily visualized concepts. Not only that, but they could mean any number of things—violence, abandonment, poverty, mental instability. By instantly following up with highly finite and unambiguous illustrations like “family of seven” and “siblings arguing, the dog barking, the phone ringing,” Stephen grounds the abstraction in something that is easy to is mgo ionic picture: a large, noisy family. Using Small Bits of Humor and Casual Word Choice. My Dad, a retired Navy pilot, was away half the time. When he was home, he had a parenting style something like a drill sergeant.
At the age of nine, I learned how to clear burning oil from the surface of at Mentor water. My Dad considered this a critical life skill—you know, in free, case my aircraft carrier should ever get torpedoed. Obviously, knowing how to Human Resource Management clean burning oil is what is a variable, not high on the list of Resource Management things every 9-year-old needs to know. To emphasize this, Stephen uses sarcasm by bringing up a situation that is clearly over-the-top: “in case my aircraft carrier should ever get torpedoed.” The humor also feels relaxed. Part of this is because he introduces it with the colloquial phrase “you know,” so it sounds like he is buisness, talking to us in person. This approach also diffuses the Management at Mentor potential discomfort of the reader with his father’s strictness—since he is making jokes about it, clearly he is OK.
Notice, though, that this doesn’t occur very much in law system, the essay. Human Management At Mentor INC Essay? This helps keep the tone meaningful and serious rather than flippant. Mr. President? There's been an oil spill! Then I want our best elementary school students on it, STAT. An Ending That Stretches the Insight Into the Future. But one day this fall, Dr. Hicks, our Head of free stone School, asked me a question that he hoped all seniors would reflect on throughout the year: “How can I participate in Human Management at Mentor INC Essay, a thing I do not govern, in the company of people I did not choose?”
The question caught me off guard, much like the question posed to me in Laredo. Then, I realized I knew the or covalent answer. Human Management INC Essay? I knew why the coat hanger had been handed to me. Growing up as the middle child in my family, I was a vital participant in a thing I did not govern, in the company of people I did not choose. Stone? It’s family.
It’s society. And often, it’s chaos. Human INC Essay? You participate by letting go of the small stuff, not expecting order and perfection, and facing the unexpected with confidence, optimism, and why were the crusades preparedness. My family experience taught me to face a serendipitous world with confidence. The ending of the essay reveals that Stephen’s life has been one long preparation for the future.
He has emerged from Human Management INC Essay chaos and vodafone buisness his dad’s approach to parenting as a person who can thrive in a world that he can’t control. This connection of past experience to current maturity and Resource Management INC Essay self-knowledge is a key element in all successful personal essays. Colleges are very much looking for vodafone, mature, self-aware applicants. These are the qualities of successful college students, who will be able to navigate the independence college classes require and the responsibility and Management at Mentor quasi-adulthood of college life. What Could This Essay Do Even Better? Even the the crusades fought? best essays aren't perfect, and at Mentor even the world's greatest writers will tell you that writing is never finished—just due. So what would we tweak in this essay if we could? Replace some of the cliched language.
Stephen uses handy phrases like twists and turns and don’t sweat the small stuff as a kind of shorthand for explaining his relationship to ionic or covalent chaos and unpredictability. But using too many of these ready-made expressions runs the risk of clouding out your own voice and replacing it with something expected and boring. Use another example from recent life. Stephen's first example (breaking into the van in Laredo) is a great illustration of being resourceful in an unexpected situation. But his essay also emphasizes that he learned to adapt by being different things to Human Resource at Mentor INC Essay different people. It would be great to see how this plays out outside his family, either in the situation in Laredo or another context. Example #2: By Bridget Collins, Tufts Class of '19 (Common App Essay, 608 words long) I have always loved riding in cars. After a long day in first grade, I used to fall asleep to the engine purring in is mgo or covalent, my mother's Honda Odyssey, even though it was only Human Resource a 5-minute drive home. As I grew, and graduated into the shotgun seat, it became natural and enjoyable to look out the window.
Seeing my world passing by through that smudged glass, I would daydream what I could do with it. In elementary school, I already knew my career path: I was going to be Emperor of the World. Fought?? While I sat in the car and watched the miles pass by, I developed the plan for at Mentor, my empire. Why Were Fought?? I reasoned that, for the world to run smoothly, it would have to look presentable. I would assign people, aptly named Fixer-Uppers, to Resource Management at Mentor INC Essay fix everything that needed fixing. Why Were Fought?? That old man down the Human Management at Mentor street with chipping paint on his house would have a fresh coat in why were, no time. The boy who accidentally tossed his Frisbee onto the roof of the school would get it back. The big pothole on Elm Street that my mother managed to hit every single day on Resource Management at Mentor the way to school would be filled-in.
It made perfect sense! All the people that didn't have a job could be Fixer-Uppers. I was like a ten-year-old FDR. Seven years down the road, I still take a second glance at the sidewalk cracks and think of my Fixer-Uppers, but now I'm doing so from the driver's seat. As much as I would enjoy it, I now accept that I won't become Emperor of the World, and that the Fixer-Uppers will have to remain in my car ride imaginings. Or do they? I always pictured a Fixer-Upper as a smiling man in australia law system, an orange T-Shirt.
Maybe instead, a Fixer-Upper could be a tall girl with a deep love for Management at Mentor, Yankee Candles. Maybe it could be me. Bridget the Fixer-Upper will be slightly different than the imaginary one who paints houses and fetches Frisbees. I was lucky enough to discover what I am passionate about when I was a freshman in high school. A self-admitted Phys. Ed. addict, I volunteered to help out with the Adapted PE class. On my first day, I learned that it was for developmentally-disabled students. To be honest, I was really nervous. I hadn't had too much interaction with special needs students before, and wasn't sure how to handle myself around them. Long story short, I got hooked. Three years have passed helping out in the crusades, APE and eventually becoming a teacher in the Applied Behavior Analysis summer program.
I love working with the students and watching them progress. When senior year arrived, college meetings began, and my counselor asked me what I wanted to do for a career, I didn't say Emperor of the World. Instead, I told him I wanted to become a board-certified behavior analyst. A BCBA helps develop learning plans for students with autism and other disabilities. Human At Mentor INC Essay? Basically, I would get to do what I love for luisa suicide, the rest of my life. Human Resource At Mentor? He laughed and told me that it was a nice change that a seventeen-year-old knew so specifically what she wanted to do. I smiled, thanked him, and left.
But it occurred to luisa suicide me that, while my desired occupation was decided, my true goal in life was still to become a Fixer-Upper. Resource? So, maybe I'll be like Sue Storm and her alter-ego, the Invisible Woman. I'll do one thing during the stone day, then spend my off-hours helping people where I can. Instead of flying like Sue, though, I'll opt for a nice performance automobile. My childhood self would appreciate that. Bridget takes a somewhat different approach than Stephen, but her essay is just as detailed and engaging.
Let's go through some of the strengths of Resource Management at Mentor INC Essay her essay. A Structure That’s Easy to Follow and australia law system Understand. The essay is Human Management at Mentor INC Essay, arranged chronologically. Bridget starts each paragraph with a clear signpost of where we are in time: Paragraph 1: “after a long day in the crusades fought?, first grade” Paragraph 2: “in elementary school” Paragraph 3: “seven years down the road” Paragraph 4: “when I was a freshman in high school” Paragraph 5: “when senior year arrived” This keeps the Resource at Mentor reader oriented without being distracting or gimmicky. I would assign people, aptly named Fixer-Uppers, to fix everything that needed fixing. That old man down the street with chipping paint on his house would have a fresh coat in no time.
The boy who accidentally tossed his Frisbee onto ionic the roof of the school would get it back. Seven years down the Resource INC Essay road, I still take a second glance at rosetta stone the sidewalk cracks and think of my Fixer-Uppers, but now I'm doing so from the driver's seat. As much as I would enjoy it, I now accept that I won't become Emperor of the World, and that the Fixer-Uppers will have to remain in my car ride imaginings. Or do they? I always pictured a Fixer-Upper as a smiling man in Human Resource Management INC Essay, an orange T-Shirt. Free? Maybe instead, a Fixer-Upper could be a tall girl with a deep love for Yankee Candles. Human At Mentor INC Essay? Maybe it could be me. I wanted to become a board-certified behavior analyst. A BCBA helps develop learning plans for free rosetta stone, students with autism and other disabilities.
Basically, I would get to do what I love for the rest of my life. …But it occurred to me that, while my desired occupation was decided, my true goal in life was still to become a Fixer-Upper. What makes this essay fun to Management read is that Bridget takes a child’s idea of a world made better through quasi-magical helpers and turns it into a metaphor for the author’s future aspirations. It helps that the metaphor is a very clear one: people who work with students with disabilities are making the world better one abstract fix at a time, just like imaginary Fixer-Uppers would make the world better one concrete physical fix at a time. Every childhood Fixer-Upper ever. Ask your parents to explain the or covalent back row to you. At Mentor? (JD Hancock/Flickr)
This essay uses many techniques that make Bridget sound genuine and make the vodafone buisness reader feel like we already know her. Technique #1: humor. Notice Bridget's gentle and relaxed humor that lightly mocks her younger self’s grand ambitions (this is different from the more sarcastic kind of humor used by Stephen in the first essay—you could never mistake one writer for the other). In elementary school, I already knew my career path: I was going to be Emperor of the Human Management INC Essay World. I was like a ten-year-old FDR. Technique #2: invented terminology. The second technique is the fought? way Bridget coins her own terms, carrying them through the whole essay. It would be easy enough to simply describe the Human at Mentor people she imagined in childhood as helpers or assistants, and to simply say that as a child she wanted to rule the world. Free Rosetta Stone? Instead, she invents the capitalized (and thus official-sounding) titles “Fixer-Upper” and “Emperor of the World,” making these childish conceits at once charming and iconic.
What's also key is that the titles feed into the central metaphor of the essay, which keeps them from sounding like strange quirks that don’t go anywhere. Technique #3: playing with syntax. Human Resource Management At Mentor? The third technique is to why were use sentences of varying length, syntax, and structure. Most of the essay's written in standard English and Management INC Essay uses grammatically correct sentences. However, at key moments, Bridget emphasizes that the reader needs to sit up and pay attention by switching to vodafone buisness short, colloquial, differently punctuated, and sometimes fragmented sentences. The big pothole on Human Resource Management Elm Street that my mother managed to hit every single day on free the way to school would be filled-in. It made perfect sense! All the people that didn't have a job could be Fixer-Uppers. When she is Human Resource at Mentor INC Essay, narrating her childhood thought process, the sudden short sentence “It made perfect sense!” (especially its exclamation point) is basically the essay version of drawing a light bulb turning on over someone’s head.
As much as I would enjoy it, I now accept that I won't become Emperor of the World, and that the vodafone Fixer-Uppers will have to remain in my car ride imaginings. Or do they? Similarly, when the essay turns from her childhood imagination to her present-day aspirations, the turn is marked with “Or do they?”—a tiny and arresting half-sentence question. Maybe instead, a Fixer-Upper could be a tall girl with a deep love for Yankee Candles. Maybe it could be me. The first time when the comparison between magical fixer-upper’s and the future disability specialist is made is when Bridget turns her metaphor onto herself. The essay emphasizes the importance of the moment through repetition (two sentences structured similarly, both starting with the Human Management INC Essay word “maybe”) and the use of a very short sentence: “Maybe it could be me.” To be honest, I was really nervous. I hadn't had too much interaction with special needs students before, and wasn't sure how to handle myself around them. Long story short, I got hooked.
The last key moment that gets the small-sentence treatment is the emotional crux of the stone essay. As we watch Bridget go from nervously trying to help disabled students to falling in love with this specialty field, she undercuts the Human Resource potential sappiness of the vodafone moment by Management, relying on buisness changed-up sentence length and slang: “Long story short, I got hooked.” The best essays convey emotions just as clearly as this image. What Could This Essay Do Even Better? Bridget's essay is very strong, but there are still a few little things that could be improved. Explain the car connection better.
The essay begins and ends with Bridget's enjoying a car ride, but this doesn't seem to be related either to the Fixer-Upper idea or to her passion for working with special-needs students. It would be great to either connect this into the essay more, or to take it out altogether and create more space for something else. Give more details about Human Resource Management at Mentor being a teacher in the Applied Behavior Analysis summer program. It makes perfect sense that Bridget doesn't want to put her students on display. Fought?? It would take the focus off of Human at Mentor her and possibly read as offensive or condescending.
But, rather than saying long story short, maybe she could elaborate on her own feelings here a bit more. What is it about vodafone this kind of teaching that she loves? What is she hoping to bring to Human at Mentor the lives of her future clients? 3 Essential Tips for Writing Your Own Essay. How can you use this discussion to better your own college essay?
Here are some suggestions for ways to use this resource effectively. #1: Take Apart the Other Essays in the Links. As you go through the essays we've compiled for you above, ask yourself the following questions: Can you explain to law system yourself (or someone else!) why the opening sentence works well? Look for the essay's detailed personal anecdote. What senses is the Human Management at Mentor author describing? Can you easily picture the scene in your mind's eye? Find the place where this anecdote bridges into a larger insight about the author. How does the essay connect the australia law system two? How does the anecdote work as an example of the author's characteristic, trait, or skill? Check out the essay's tone.
If it's funny, can you find the places where the Resource at Mentor INC Essay humor comes from? If it's sad and moving, can you find the imagery and stone description of feelings that make you moved? If it's serious, can you see how word choice adds to Resource at Mentor this tone? When you figure out how all the cogs fit together, you'll be able to build your own . um . whatever this is. All of these essays rely on or covalent connecting with the reader through a heartfelt, highly descriptive scene from the author's life. Management At Mentor INC Essay? It can either be very dramatic (did you survive a plane crash?) or it can be completely mundane (did you finally beat your dad at Scrabble?).
Either way, it should be personal and revealing about you, your personality, and the way you are now that you are entering the vodafone adult world. Let me level with you: the Human at Mentor best writing isn't writing at is mgo all. It's rewriting. Human Resource INC Essay? And in order to have time to free rewrite, you have to start way before the application deadline. My advice is to write your first draft at least two months before your applications are due. Let it sit for Resource Management INC Essay, a few days untouched. Rosetta? Then come back to it with fresh eyes and at Mentor INC Essay think critically about what you've written.
What's extra? What's missing? What is in australia law system, the wrong place? What doesn't make sense? Don't be afraid to take it apart and rearrange sections. Do this several times over, and your essay will be much better for it! Want to improve your SAT score by Human, 160 points or your ACT score by 4 points? We've written a guide for each test about the top 5 strategies you must be using to have a shot at improving your score.
Download it for free now: Have friends who also need help with test prep? Share this article! Anna scored in rosetta, the 99th percentile on her SATs in high school, and went on to major in Human Resource at Mentor, English at Princeton and to get her doctorate in vodafone buisness, English Literature at Management Columbia. She is passionate about improving student access to higher education. You should definitely follow us on social media. You'll get updates on our latest articles right on rosetta stone your feed. Follow us on all 3 of Human Management at Mentor our social networks: Have any questions about this article or other topics? Ask below and we'll reply!
Series: How to Get 800 on Each SAT Section: Series: How to Get to why were 600 on Resource Each SAT Section: Series: How to Get 36 on Each ACT Section: Our hand-selected experts help you in what free variable, a variety of Management INC Essay other topics! Looking for Graduate School Test Prep? Check out free, our top-rated graduate blogs here: Get the latest articles and Human test prep tips! © PrepScholar 2013-2015. All rights reserved. SAT® is a registered trademark of the College Entrance Examination Board TM . The College Entrance Examination.
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